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Sometimes, a sissy (or the alpha who has the pleasure of feminizing her) may pursue chemical means for her sissification. These chemicals can change her biology on a fundamental level, alter her mental state to make her more pliant towards masculine partners and more submissive towards attempts to humiliate her completely, or give her a straight-up addiction to alpha cum! Whatever these serums do, their effects tend to be irreversible if they're allowed to react with alpha cum while the sissy is still under their effects... so if you take one, it might be smartest to avoid being the little sissy slut you are for just one night. You can manage that much... right?
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