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In the distant future, a strange virus had plagued the Earth. Humans slowly died off, and civilization itself started to collapse. However, in due time, women started developing an immunity to this virus known as the Sapphic Strain. It not only made them immune to the virus, but also started creating a number of changes in their body. One of the biggest changes was the eventual development of Parthenogenesis, no longer requiring men for pregnancy.
Men, however remained vulnerable to the virus, and their numbers continued to dwindle. Humanity was slowly able to restore itself, but women have become the future. The very few men are now locked up in labs for experimentation, to see if the Sapphic Strand can also be passed to them. Unfortunately, their biological structure is unable to handle the strand, and instead causes them to turn into beasts that surrenders to desire. The only way to stop them would be emasculation.