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The female body developed a new antibody known as the Sapphic Strand. It has allowed them to resists various diseases and infections. Ironically, the strand also views male presence as an infection. Whenever a man goes inside her, the antibody would react and send a chemical that would cause massive swelling of the cock and balls, which would also make it feel as if the organ is being melted from within. So far, the only way to escape the pain is complete emasculation.